Beilstein J. Org. Chem.2008,4, No. 53, doi:10.3762/bjoc.4.53
-donor, in the presence of catalytic ruthenium trichloride is described. Aromatic aldehydes and 1,2-diketones are reduced efficiently and selectively, while aryl ketones remain unchanged. Several other potentially reducible groups attached to the aromatic moiety are unaffected.
Keywords: Amberlite
® resins; chemoselectivity; hydrogen transfer; reduction of carbonyl group; ruthenium chloride; Introduction
Reduction of carbonyl functionality by transition metal-catalyzed transfer hydrogenation (CTH) with the aid of a suitable hydrogen donor is a valuable synthetic tool and has proved to be a viable
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Graphical Abstract
Scheme 1:
RuCl3-catalyzed transfer hydrogenation of aryl aldehydes.